A 'first map - round handicap' market involves giving one team an advantage (or a disadvantage) in the number of rounds they are required to win in the first map of a match. This market will apply to CS:GO and any other game that has round-based scoring.
For example, if there is a best of 3 match between 2 teams, you can bet on Team A with a 'round handicap' of +3.5 for the first match. Team A will already have a 3.5 map advantage, so they will only need to win at least 13 rounds in the first match, in order to win the bet. Team A can lose the first map 13-16, or closer, or win the first match, for you to win the bet.
Alternatively, you can bet on Team B which has a -3.5 'round handicap'. This means that Team B starts with a -3.5 round disadvantage in the first map. Team B must win by at least 16-12, or by a larger margin, for you to win the bet.